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Description

Basic polymeric nanocarrier systems significantly enhance the therapeutic efficacy in gout treatment through multi-pathway synergistic mechanisms

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2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) (63)

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To put this in perspective, in a 200-pound person, 1 percent weight-loss is two pounds and 5 percent is 10 pounds lost

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